Efficient DNA binding requires heterodimerization of an alpha and a beta/ARNT subunit.
Function:
Functions as a master transcriptional regulator of the adaptive response to hypoxia. Binds to core DNA sequence 5'-[AG]CGTG-3' within the hypoxia response element (HRE) of target gene promoters. Activation requires recruitment of transcriptional coactivators.
Subcellular Location:
Cytoplasm
Nucleus
Cytoplasmic in normoxia, nuclear translocation in response to hypoxia.
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Precision
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Recovery
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Linearity
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References
1.
"Molecular cloning and expression of an avian cDNA for hypoxia-inducible factor-1 alpha in embryonic ventricular myocytes." Takahashi T.
Submitted (1998-05) to the EMBL/GenBank/DDBJ databases
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Cited for: NUCLEOTIDE SEQUENCE [MRNA]